Disease Modeling

Products & Services / Disease Modeling

The ability to model human disease in the lab is critical for understanding pathogenesis and developing effective therapies. Traditional 2D cell cultures and animal models often fail to capture the structural and functional complexity of human organs. Organoids — three-dimensional miniaturized tissues derived from stem cells or patient samples — offer a physiologically relevant system that bridges the gap between in vitro and in vivo models.

Accelerate Preclinical Discovery with Predictive Modeling

Our modeling platform combines human-derived and animal-based systems to deliver clinically relevant insights into disease pathways and therapeutic responses.

From cardiovascular disorders to multi-organ interactions, we provide tools that bring you closer to predicting patient outcomes – earlier and more cost-effectively.

Representative Applications

Neurological Diseases

Brain organoids model viral-induced microcephaly, as seen in Zika virus infection, allowing the study of viral neurotoxicity and early brain development.

Infectious Diseases

Multi-organ organoids (liver, gut, kidney, and vascular) were instrumental in COVID-19 research, revealing how SARS-CoV-2 infects multiple tissues and enabling testing of inhibitors such as recombinant soluble ACE2.

Gastrointestinal Disorders

Intestinal organoids provide platforms for culturing enteric viruses like norovirus and rotavirus, supporting antiviral drug screening and infection mechanism studies.

Genetic Diseases

Rectal organoids derived from patient biopsies model cystic fibrosis, enabling personalized drug testing using forskolin-induced swelling assays to assess CFTR function.

Cancer and Precision Oncology

Patient-derived tumor organoids (PDOs) retain the genetic and microenvironmental complexity of native tumors. Drug responses in these models correlate with patient outcomes in up to 90% of cases, providing a predictive platform for therapy selection.

Resources

Cugola, F. R. et al. The Brazilian Zika virus strain causes birth defects in experimental models. Nature 534, 267–271 (2016).
Yoon, K. J. et al. Zika-virus-encoded NS2A disrupts mammalian cortical neurogenesis by degrading adherens junction proteins. Cell Stem Cell 21, 349–358 (2017).
Dekkers, J. F. et al. Characterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosis. Sci. Transl. Med. 8, 344ra384 (2016).

Looking for a customized solution?

With deep expertise in organoid systems, we support cell-based experiments at every stage — streamlining workflows, reducing operational burden, and ensuring robust, high-quality data generation.

Products & Services / Disease Modeling